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Olestra
Olestra represents the most disastrous use of a branded ingredient to date. Frito-Lay unveiled their WOW line of snacks in 1998 to $400 million in sales, but Olestra caused bowel problems and attracted mockery from prime-time comedies. By 2000, that figure fell to $200 million, and by 2003 the snack-food company reformulated the line and renamed it altogether.